Composition (in 1 ml (20 drops) solution) 
Active ingredients: 
Elemental iron - 25 mg (microencapsulated Fe3+ pyrophosphate 167 mg), 
Folic acid 300 mcg, vitamin B12 2 mcg, vitamin C 40 mg. 
Auxiliary substances:water, fructose, potassium sorbate, citric acid, black cherry sweetener. 

Product Information 
Tempiron is a combined anti-anemic agent containing iron pyrophosphate, folic acid, B12 and C vitamins prepared by microencapsulation technology. Tempiron drops are used to meet the daily requirement of iron or to eliminate iron deficiency. 
Microencapsulated iron is a unique and state-of-the-art microionized iron pyrophosphate compound. Iron is the main component of hemoglobin, myoglobin and some enzymes. Iron ions contribute to the formation of red blood cells and hemoglobin, the transport of oxygen in the body, the normal functioning of the immune system, energy production, and the reduction of fatigue and physical exhaustion. Iron pyrophosphate, made by nanotechnology and resistant to oxidation, is absorbed from the small intestine without breaking down in the digestive tract. Absorption of iron pyrophosphate is carried out by the M cells of the small intestine (special cells located in the epithelium in areas with lymphoid follicles (Peyer's nodes). Since M cells are located throughout the small intestine, absorption of microencapsulated iron occurs along the entire length of the small intestine, ensuring high bioabsorption and efficiency of iron ions. Absorbed iron pyrophosphate is released from the protective layer in the liver, then combines with the transferrin protein and is used for the synthesis of hemoglobin in the bone marrow, or combines with ferritin and is stored in the liver. Unabsorbed iron is excreted in the feces. Microencapsulated iron does not come into contact with the gastric mucosa, and is delivered to the target organs without irritating the stomach or damaging the digestive tract. Folic acid is a precursor of tetrahydrofolate, a coenzyme of various metabolic processes (including the biosynthesis of purines and thymidylates of nucleic acids), belonging to group B vitamins, synthesized in the body by intestinal microflora. Folic acid is metabolized in intestinal and liver cells, as well as in other organs. Processed folates are combined with proteins and transported to all organs. Together with vitamin B12, it stimulates the process of hematopoiesis, partially erythropoiesis, is important for the normal development of red blood cells, including the formation and maturation of megaloblasts, as well as the formation of normoblasts. It participates in the synthesis of amino acids (including methionine, serine, glycine and histidine), nucleic acids, purines, pyrimidines, choline metabolism in the liver, prevents fat infiltration. During pregnancy, folic acid protects the body from the effects of teratogenic factors, plays an important role in the normal formation of the embryo's nervous system, and prevents the development of neural tube defects. Vitamin B12 participates in the synthesis of purine and pyrimidine bases, nucleic acids, which play an important role in erythropoiesis, and ensures the active accumulation of sulfhydryl compounds in erythrocytes. It also participates in hydrogen transport and transmethylation processes, activates methionine synthesis. It has an anabolic effect by increasing the synthesis and accumulation of proteins in the body. In combination with folic acid, it prevents macrocytic anemia. Vitamin C (ascorbic acid) is not synthesized in the body, it is received only through food. Ascorbic acid enhances the absorption of iron and helps increase its bioavailability. It participates in oxidation-reduction reactions, carbohydrate metabolism, tissue regeneration, increases the body's resistance to infections. It participates in carbohydrate utilization, lipid, protein, carnitine synthesis and immune reactions. It has a strong antioxidant and antiaggregant effect. 

Instructions for use 
- Overt deficiency anemias (iron, folic acid and vitamin B12 deficiency anemias) 
- Latent (not accompanied by anemia) iron deficiency 
- Increased demand for iron during the period of intensive growth (in children and adolescents, as well as in women of reproductive age) (prevention of iron deficiency) 
- Increased iron demand during pregnancy (second and third trimester), lactation, blood donation, hemodialysis, low-calorie, vegetarian and unbalanced diet, old age (prevention of iron deficiency) 
- Chronic hemorrhages (gastrointestinal, bladder, hemorrhoidal, nasal and uterine bleeding) 
- Anemias caused by worm diseases (helminthiasis) 
- Combined iron-folic acid-vitamin B12 deficiency (related to infections, chronic alcoholism) 
- In the period after surgical operations, acute infectious diseases, chronic diseases, harmful environmental 
Anemias caused by the effects of factors 
-Anemias caused by long-term use of various medicinal products (acetylsalicylic acid and other NSAIDS, anticoagulants, hormonal, psychotropic, oral contraceptives and anticonvulsants). 

Contraindications:- Hypersensitivity to any of the substances contained in the preparation. -Disorders of iron absorption (for example, lead anemia, sideroacrestic anemia, thalassemia). -Regularly required blood transfusions. -Overloading of the body with iron (for example, hemosiderosis, hemochromatosis). -Anemia not related to iron, folic acid, and vitamin B12 deficiency (eg, hemolytic anemia, aplastic anemia). -Severe liver and/or kidney failure. 

Method of use and dosage 
1 ml (20 drops) of solution contains 25 mg, and 1 drop contains 1.25 mg of elemental iron (Fe3+). 
The preventive dose is 1 mg/kg/day, the therapeutic dose is 2-4 mg/kg/day according to the amount of elemental iron. The daily therapeutic dose of the drug depends on the degree of iron deficiency and is determined individually by the doctor. 
Instructions for use: Received in. The daily dose can be divided into several doses or taken at once. Tempiron is taken during or immediately after a meal. The drops can be mixed with fruit and vegetable juices or baby food or non-alcoholic drinks. Slight coloring of the mixture does not affect the taste of the juice/baby food or the effectiveness of the preparation. 
Use the following doses unless otherwise prescribed by a doctor. 
Prevention of iron deficiency during increased demand for iron (Treatment duration is about 1-2 months). 
Children up to 4 years: 4-8 drops (5-10 mg elemental iron)/day 
Children aged 4-7 years: 10 drops (12.5 mg elemental iron)/day 
Children aged 7-14 years: 15 drops (18.75 mg elemental iron)/day 
Children and adults over 14 years: 20 drops (25 mg elemental iron)/day 
Iron deficiency not accompanied by anemia (latent iron deficiency). The duration of treatment is about 1-2 months. 
Up to 4 years: 8-12 drops (10-15 mg iron)/day 
Children 4-7 years: 12-20 drops or 0.6-1 ml (15-25 mg iron)/day 
Children 7-14 years: 20-40 drops or 1-2 ml (25-50 mg iron)/day 
Children and adults over 14 years: 40-80 drops or 2-4 ml (50-100 mg iron)/day 
Iron-deficiency anemia (treatment is carried out until the normal level of hemoglobin is achieved and the duration is about 3-5 months. Then, in order to restore the iron reserve, the treatment is continued for at least 1 more month at the dose prescribed for iron deficiency not accompanied by anemia)._cc781905- 5cde-3194-bb3b-136bad5cf58d_
Up to 4 years: 12-20 drops or 0.6-1 ml (15-25 mg iron)/day 
Children aged 4-7 years: 20-40 drops or 1-2 ml (25-50 mg iron)/day 
Children 7-14 years: 40-80 drops or 2-4 ml (50-100 mg iron)/day 
Children and adults over 14 years: 80-240 drops or 4-12 ml (100-300 mg iron)/day 
The order of admission can be adjusted by the doctor. 

Release form:Dropper for internal administration in a dark glass bottle equipped with a dropper-pipette. 
 
Producer:Inalme srl, Italy.